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Pyruvate kinase is really a terminal enzyme from the glycolytic pathway, the place it catalyzes the conversion of phosphoenolpyruvate to pyruvate and production of ATP through substrate level phosphorylation. PKM2 is among 4 isoforms of pyruvate kinase and is also extensively expressed in several different types of tumors and linked to tumorigenesi

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However, experiments performed in the xanthine-xanthine oxidase technique confirmed that it didn't inhibit the production of O2?? This final result suggests that it is not a scavenger of O2?? It also inhibited the PMN metabolic reaction by inhibiting O2??[183].Treatment with two hundred nM cepharanthine by itself was capable of improve the inhibito

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